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Pre-treatment of Vero cells with human IFN resulted in reduction of pprv replication, confirming the role of IFN in limiting pprv replication.
Water buffalo produced higher levels of interferon (IFN) in comparison with goats at transcriptional and translational levels.
We investigated the role of TLR and cytokines in differential susceptibility of goat breeds and water buffalo to pprv.Upon stimulation of pbmc with synthetic TLR3 and TLR7 agonists or pprv, the levels of proinflammatory cytokines were found to be significantly higher while immunosuppressive interleukin (IL) 10 levels were lower in pprv resistant Kanni and Salem Black breeds and water buffalo at transcriptional level.We examined the replication of pprv in peripheral blood mononuclear cells (pbmc) of Indian domestic goats and water buffalo and demonstrated that the levels of TLR3 and TLR7 and downstream signalling molecules correlation with susceptibility vs resistance.Cerca, newsletter, ovine rinderpest or goat plague.Analyzing other host genetic factors might provide further insights on susceptibility to pprv and genetic polymorphisms in the host.Grande sconto Nere Vaporous Uomo Sneaker / Converse Weapon Lp Hi Store Roma 0YBVqOg9b migliore in linea 175.08 78.19.
The host innate immune system discriminates between pathogen associated molecular patterns and self antigens through surveillance receptors known as Toll like receptors (TLR).
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